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Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal.
Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Abu-Elheiga L, et al. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12011-6. doi: 10.1073/pnas.0505714102. Epub 2005 Aug 15. Proc Natl Acad Sci U S A. 2005. PMID: 16103361 Free PMC article.
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. Fullerton MD, et al. Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3. Nat Med. 2013. PMID: 24185692 Free PMC article.