Format

Send to

Choose Destination
See comment in PubMed Commons below

Molecular targets and therapeutic strategies in Huntington's disease.

Author information

  • 1Faculty of Medicine, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. acrego@cnc.cj.uc.pt

Abstract

This article provides an overview of the molecular mechanisms associated with striatal neuronal degeneration in Huntington's disease (HD), the most studied of the diseases caused by polyglutamine expansion. We discuss the current status of research in cellular and animal models of HD, in which protein aggregation, excitotoxicity, mitochondrial dysfunction, transcription deregulation, trophic factor starvation and the disruption of axonal transport appear to be key features for selective striatal neurodegeneration. We further emphasize some of the most promising current strategies in HD treatment. We delineate the molecular and cellular rationale underlying the development of new pharmaceutical interventions that offer new hope of future treatment for HD patients worldwide.

PMID:
16101555
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center