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Mini Rev Med Chem. 2005 Aug;5(8):755-60.

Retinoids as therapeutic agents: today and tomorrow.

Author information

1
ALIX, Bio-Incubateur de l'ESBS, Boulevard Sebastien Brandt, 67400 Illkirch, France. vivat@alix-pharma.fr

Abstract

Retinoids have shown beneficial therapeutic effects in pre-clinical and animal models for multiple pathologic indications, however severe adverse effects, restricting dosage and efficacy of oral formulations limit their use in patients. The focus of this review includes the actual medicinal use of retinoids and chemical efforts to generate highly selective and less toxic synthetic retinoids.

PMID:
16101411
DOI:
10.2174/1389557054553820
[Indexed for MEDLINE]

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