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Nihon Rinsho. 2005 Aug;63(8):1367-71.

[Expression of transcription factor in Barrett's esophagus].

[Article in Japanese]

Author information

1
Department of Gastroenterology, Jichi Medical School.

Abstract

Barrett's esophagus is the result of chronic injury which is usually caused by gastroesophageal reflux. NF-kappaB is expressed in the reflux esophagitis. Specialized columnar epithelium (SCE) is characteristic of Barrett's esophagus and has a malignant predisposition. SCE expresses Cdx1 and Cdx2. Adenocarcinoma in Barrett's esophagus is believed to develop through the metaplasia-dysplasia-carcinoma sequence. P53, beta-catenin, PPARgamma, and estrogen receptor beta are closely related to the development of esophageal carcinogenesis.

PMID:
16101223
[Indexed for MEDLINE]
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