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Trends Microbiol. 2005 Oct;13(10):476-84.

Tyrosine-phosphorylated bacterial effector proteins: the enemies within.

Author information

1
Otto-von-Guericke-Universität Magdeburg, Institut für Medizinische Mikrobiologie, Leipziger Str. 44, D-39120 Magdeburg, Germany. steffen.backert@medizin.uni-magdeburg.de

Abstract

The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge.

PMID:
16099656
DOI:
10.1016/j.tim.2005.08.002
[Indexed for MEDLINE]

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