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Curr Opin Cell Biol. 2005 Oct;17(5):509-16.

Integrin regulation.

Author information

1
Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

Abstract

Integrin signaling is bidirectional. 'Inside-out' signals regulate integrin affinity for adhesive ligands, and ligand-dependent 'outside-in' signals regulate cellular responses to adhesion. Integrin extracellular domains are yielding to high-resolution structural analyses, and intracellular proteins involved in integrin signaling are being identified. However, a key unresolved question is how integrins propagate signals across the plasma membrane.

PMID:
16099636
DOI:
10.1016/j.ceb.2005.08.010
[Indexed for MEDLINE]

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