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Curr Opin Cell Biol. 2005 Oct;17(5):542-7.

Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition.

Author information

1
Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Glasgow G61 1BD, United Kingdom. e.avizienyte@beatson.gla.ac.uk

Abstract

Src kinase controls cellular adhesions, including cadherin-based intercellular adhesions and integrin-mediated cell-matrix adhesions. In epithelial cells, Src activation, or increased signalling from migratory growth factor receptors via Src, induces an adhesion switch that enhances dynamic cell-matrix adhesions and migratory capacity while suppressing intercellular contact. Moreover, Src and the associated tyrosine kinase FAK are at the heart of the recently identified crosstalk between integrin- and cadherin-mediated adhesions of epithelial cells, particularly during the epithelial-to-mesenchymal transition.

PMID:
16099634
DOI:
10.1016/j.ceb.2005.08.007
[Indexed for MEDLINE]

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