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FEMS Microbiol Lett. 2005 Sep 15;250(2):195-200.

Peptidoglycan precursor pools associated with MraY and FtsW deficiencies or antibiotic treatments.

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1
Enveloppes Bactériennes et Antibiotiques, UMR 8619 CNRS, Bâtiment 430, Université Paris-Sud, 91405 Orsay, France.

Abstract

Blocking peptidoglycan synthesis in Escherichia coli with moenomycin or vancomycin led to the accumulation of UDP-MurNAc-pentapeptide and of its immediate upstream precursors, whereas with cephaloridine or penicillin G the pool of UDP-MurNAc-pentapeptide decreased. With MraY and FtsW deficiencies the decrease of UDP-MurNAc-pentapeptide was accompanied by an increase of the upstream nucleotide precursors and the appearance of UDP-MurNAc-tetrapeptide.

PMID:
16099113
DOI:
10.1016/j.femsle.2005.07.005
[Indexed for MEDLINE]
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