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Am J Hematol. 1992 Jul;40(3):167-70.

Plasma cytokine levels in thrombotic thrombocytopenic purpura.

Author information

1
Second Department of Internal Medicine, Mie University School of Medicine, Mie Ken, Japan.

Abstract

Plasma cytokine levels were examined in 13 patients with thrombotic thrombocytopenic purpura (TTP). Auto-antibodies, platelet-associated immunoglobulin G, and platelet aggregating factor were detected in many of these patients and high-molecular-weight bands of von Willebrand factor multimers were reduced in 9 of 10 patients examined. Complete remission (CR) was attained in 7 of the 13 patients, but 6 died. Tumor necrosis factor (TNF), Interleukin (IL)-1 beta, IL-6, and soluble IL-2 receptor showed marked increases at onset and decreased at CR. The prognosis tended to be poor in patients with increased IL-6 and soluble IL-2 receptor levels. These findings suggest that immunological mechanisms, such as the activation of macrophage, are involved in the pathogenesis of TTP and are reflected in the plasma cytokine levels.

PMID:
1609769
DOI:
10.1002/ajh.2830400303
[Indexed for MEDLINE]

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