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Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1605-7.

Will admixture mapping work to find disease genes?

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1
Department of Genetics, Harvard Medical School, Boston, MA, USA. reich@genetics.med.harvard.usa

Abstract

Admixture mapping is the first experimentally practical method for carrying out a whole-genome association scan, and is thus a promising method for detecting risk factors for common disease. The goal of the community should now be to aggressively test whether the method is useful in practice for localizing disease genes, by carrying out at least three high-powered studies. We also propose a stringent criteria we believe the community should adopt before declaring a statistically significant admixture association to disease.

PMID:
16096110
PMCID:
PMC1609196
DOI:
10.1098/rstb.2005.1691
[Indexed for MEDLINE]
Free PMC Article
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