Format

Send to

Choose Destination
See comment in PubMed Commons below
Philos Trans R Soc Lond B Biol Sci. 2005 Aug 29;360(1460):1571-2.

The genetics of human drug response.

Author information

1
Department of Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, UK. d.goldstein@duke.edu

Abstract

The genetics of variable drug response appears to be a more tractable complex trait than common disease predisposition. This has implications for prioritizing research and for experimental design, and in particular argues for extensive use of candidate gene based approaches in pharmacogenetic association studies. Eventually, when whole genome scanning becomes feasible, it may be appropriate to consider weighting schemes that assign higher prior probabilities of variants in genes related to the mode of action of metabolism of medicines.

PMID:
16096105
PMCID:
PMC1569520
DOI:
10.1098/rstb.2005.1686
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center