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Cell. 2005 Aug 12;122(3):333-6.

How the T cell receptor sees antigen--a structural view.

Author information

1
Departments of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA. kcgarcia@stanford.edu

Abstract

Structures of many of the cell surface receptor-ligand complexes mediating the interactions between T cells and target cells have been determined in the past ten years. While snapshots of T cell receptors bound to their peptide-MHC ligands appear to have defined a general interaction or "docking" solution, many of the most fundamental structural questions in antigen recognition lack detailed answers and thus pose exciting experimental challenges for the future.

PMID:
16096054
DOI:
10.1016/j.cell.2005.07.015
[Indexed for MEDLINE]
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