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Cell. 2005 Aug 12;122(3):318-20.

Nicastrin: gatekeeper of the gamma-secretase complex.

Author information

1
Center for Human Genetics, VIB4 and KULeuven, 3000 Leuven, Belgium.

Abstract

The gamma-secretase intramembrane protease cleaves many type I membrane proteins including amyloid precursor protein and Notch, generating peptide fragments that are important signaling components. In this issue of Cell, Shah et al. (2005) reveal the function of nicastrin, the largest member of the gamma-secretase complex. They show that the nicastrin extracellular domain is essential for recognition of substrate by the gamma-secretase.

PMID:
16096051
DOI:
10.1016/j.cell.2005.07.021
[Indexed for MEDLINE]
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