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Biochem Biophys Res Commun. 2005 Sep 23;335(2):584-9.

Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection.

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Molecular Immunology, GBF, German Research Centre for Biotechnology, Braunschweig, Germany.


Type I interferons (IFNs) have been shown to be involved in many immune defence and inflammatory responses. We here show that IFN-beta plays an absolute essential role in the efficient induction of all type I IFNs after infection of primary embryonic as well as primary adult fibroblasts with Sendai virus. In contrast, after immortalization of such fibroblasts with SV40 large T antigen, IFN-alpha4 can be induced independently of IFN-beta. However, efficient secretion of type I IFNs even in immortalized fibroblasts is only found when the complete signalling loop is induced by IFN-beta.

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