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Prog Drug Res. 1992;38:133-43.

Adverse effects of fluoroquinolones.

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Division of Clinical Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.


The newer fluoroquinolones have various kinds of adverse reactions and drug-drug interactions. Patients given concurrent therapy of fluoroquinolones with theophylline should be carefully observed. It is better to avoid concurrent therapy of fluoroquinolones with NSAIDs, and patients given fluoroquinolones who have a history of central nervous system disorders should be put under careful observation, because of the possibility of central nervous system reactions. Fluoroquinolones should be carefully administered to patients with compromised renal functions, because fluoroquinolones are accumulated in patients with impaired renal function. Although fluoroquinolones have various kinds of adverse reactions, the frequency of toxicity is considered to be acceptable. However careful, clinical and experimental studies should be continued to reveal more details on the adverse reactions of fluoroquinolones.

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