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Neurology. 2005 Aug 9;65(3):472-4.

Dopaminergic effects on encoding of a motor memory in chronic stroke.

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National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20817, USA.


The effects of a single oral dose of levodopa administered in a randomized, double-blind, placebo-controlled cross-over design on formation of a motor memory were studied by a training protocol in patients with chronic stroke. Levodopa enhanced the ability of motor training to encode an elementary motor memory relative to placebo. Up-regulation of dopaminergic function may enhance motor memory formation, crucial for successful rehabilitative treatments in patients with chronic stroke.

[Indexed for MEDLINE]

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