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BMJ. 2005 Oct 8;331(7520):807. Epub 2005 Aug 8.

Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study.

Author information

1
Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, 100 Drummond Street, Carlton, Victoria 3053, Australia. laura.baglietto@cancervic.org.au

Abstract

OBJECTIVE:

To evaluate the effect of dietary folate intake on the relation between alcohol consumption and breast cancer risk.

DESIGN:

Prospective cohort study.

SETTING:

Melbourne, Australia.

PARTICIPANTS:

17,447 Anglo-Australian women resident in Melbourne, aged 40-69 years at recruitment in 1990-4, and followed up until 31 December 2003.

MAIN OUTCOME MEASURE:

Invasive breast cancers diagnosed during follow-up and ascertained through the Victorian cancer registry.

RESULTS:

537 invasive breast cancers were diagnosed. Compared with lifetime abstainers, the hazard ratio for breast cancer in women who consumed an average of 40 g or more of alcohol daily at baseline was 1.41 (95% confidence interval 0.90 to 2.23). No direct association was found between dietary folate intake and risk of breast cancer, but a high folate intake mitigated the excess risk associated with alcohol. The estimated hazard ratio of an alcohol consumption of 40 g/day or more was 2.00 (1.14 to 3.49) for women with intakes of 200 mug/day of folate and 0.77 (0.33 to 1.80) for 400 mug/day of folate (P = 0.04 for interaction between alcohol and folate).

CONCLUSIONS:

An adequate dietary intake of folate might protect against the increased risk of breast cancer associated with alcohol consumption.

PMID:
16087654
PMCID:
PMC1246078
DOI:
10.1136/bmj.38551.446470.06
[Indexed for MEDLINE]
Free PMC Article

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