Format

Send to

Choose Destination
J Neuroimmunol. 2005 Oct;167(1-2):210-4.

Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis.

Author information

1
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Mathula.Thangarajh@neurotec.ki.se

Abstract

B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL-a promotor of B-cell survival-in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing-remitting MS, albeit not significantly. MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.

PMID:
16087247
DOI:
10.1016/j.jneuroim.2005.06.024
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center