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Clin Immunol. 2005 Sep;116(3):202-7.

Immune regulation of gammadelta T cell responses in mycobacterial infections.

Author information

1
Department of Microbiology and Immunology, Center for Primate Biomedical Research, University of Illinois College of Medicine Chicago, 835 South Wolcott Avenue, MC790, Chicago, IL 60612, USA. zchen@uic.edu

Abstract

Antigen-specific gammadelta T cells may play a role in anti-mycobacterial immunity. Studies done in humans and animal models have demonstrated complex patterns of gammadelta T cell immune responses during early mycobacterial infections and chronic tuberculosis. Recent studies have also shown a clinical correlation between major recall expansion of antigen-specific gammadelta T cells and immunity against fatal early mycobacterial diseases. Multiple host and microbial factors can regulate diverse immune responses of phosphoantigen-specific gammadelta T cells during mycobacterial infections.

PMID:
16087145
PMCID:
PMC2869281
DOI:
10.1016/j.clim.2005.04.005
[Indexed for MEDLINE]
Free PMC Article

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