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Genome Biol. 2005;6(8):R72. Epub 2005 Aug 1.

Genome-wide promoter extraction and analysis in human, mouse, and rat.

Author information

1
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. xuan@cshl.edu

Abstract

Large-scale and high-throughput genomics research needs reliable and comprehensive genome-wide promoter annotation resources. We have conducted a systematic investigation on how to improve mammalian promoter prediction by incorporating both transcript and conservation information. This enabled us to build a better multispecies promoter annotation pipeline and hence to create CSHLmpd (Cold Spring Harbor Laboratory Mammalian Promoter Database) for the biomedical research community, which can act as a starting reference system for more refined functional annotations.

PMID:
16086854
PMCID:
PMC1273639
DOI:
10.1186/gb-2005-6-8-r72
[Indexed for MEDLINE]
Free PMC Article

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