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Semin Cell Dev Biol. 2005 Dec;16(6):647-54. Epub 2005 Aug 5.

Genetic network during neural crest induction: from cell specification to cell survival.

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Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK.


The concerted action of extracellular signals such as BMP, Wnt, FGF, RA and Notch activate a genetic program required to transform a naïve ectodermal cell into a neural crest cell. In this review we will analyze the extracellular signals and the network of transcription factors that are required for this transformation. We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step.

[Indexed for MEDLINE]

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