Send to

Choose Destination
J Proteome Res. 2005 Jul-Aug;4(4):1143-54.

Place of pattern in proteomic biomarker discovery.

Author information

The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02141, USA.


The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center