Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell Cycle. 2005 Aug;4(8):1019-21. Epub 2005 Aug 7.

The first 30 minutes in the life of a virus: unREST in the nucleus.

Author information

1
Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, Chicago, Illinois 60637, USA. Bernard.Roizman@bsd.uchicago.edu

Abstract

On entry of viral DNA into cells, a competition ensues between cellular factors that silence viral genes and transcriptional factors that block silencing and transcribe the DNA. In the case of herpes simplex virus 1, the first set of genes expressed after infection-are induced by a viral protein (alphaTIF or VP16). Expression of later (beta,gamma) genes in cells infected at low ratios of virus per cells requires a transcriptional activator (ICP4) that cannot block silencing and a protein, ICP0, hitherto characterized as a promiscuous transactivator. Recent studies indicate that ICP0 blocks silencing of viral DNA by dissociating HDACs 1 and 2 from the CoREST/REST repressor complex. HDACs 1/2 are phosphorylated and translocated to the nucleus. The findings have broad implications regarding silencing of the viral genome during latency and, potentially, the expression of genes encoded by other DNA viruses as well.

PMID:
16082207
DOI:
10.4161/cc.4.8.1902
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis
    Loading ...
    Support Center