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Cancer Genet Cytogenet. 2005 Aug;161(1):78-81.

Acute myelogenous leukemia with tetrasomy 8 is a disease with a poor prognosis.

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1
Second Department of Internal Medicine, Propaedeutic, Haematology Unit, University of Athens, Attikon Hospital, 1 Rimini Street, Haidari 124 62, Greece.

Abstract

Tetrasomy 8 is an extremely rare chromosome abnormality, one that has been reported in only a few cases with myeloid malignancies. The majority of reported cases consist of acute myelogenous leukemias (AML) of monocytic lineage. In slightly more than half of the patients, tetrasomy 8 was the single cytogenetic abnormality. Fluorescence in situ hybridization revealed tetrasomy 8 and trisomy 8 concurrently in all but one of the bone marrow samples. The clonal relationship between trisomy 8 and tetrasomy 8 in these cases remains to be clarified. Patients with tetrasomy 8 have a poor prognosis, and only 1 out of 33 patients was free of disease 3 years after autologous bone marrow transplantation. Here, we report the case of a 25-year-old female patient with monocytic leukemia and tetrasomy 8.

[Indexed for MEDLINE]

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