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Am J Hum Genet. 2005 Sep;77(3):408-19. Epub 2005 Jul 14.

Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122.

Author information

1
Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Kunming, China. sub@mail.kiz.ac.cn.

Abstract

The prehistoric peopling of East Asia by modern humans remains controversial with respect to early population migrations. Here, we present a systematic sampling and genetic screening of an East Asian-specific Y-chromosome haplogroup (O3-M122) in 2,332 individuals from diverse East Asian populations. Our results indicate that the O3-M122 lineage is dominant in East Asian populations, with an average frequency of 44.3%. The microsatellite data show that the O3-M122 haplotypes in southern East Asia are more diverse than those in northern East Asia, suggesting a southern origin of the O3-M122 mutation. It was estimated that the early northward migration of the O3-M122 lineages in East Asia occurred approximately 25,000-30,000 years ago, consistent with the fossil records of modern humans in East Asia.

PMID:
16080116
PMCID:
PMC1226206
DOI:
10.1086/444436
[Indexed for MEDLINE]
Free PMC Article

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