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Nat Rev Cancer. 2005 Sep;5(9):735-43.

Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis.

Author information

  • 1Laboratory of Angiogenesis Research, Microbiology and Tumour Biology Center, Karolinska Institute, 171 77 Stockholm, Sweden. yihai.cao@mtc.ki.se

Abstract

Malignant tumours can spread to lymph nodes through lymphatic vessels. Recent studies show that tumours produce a range of growth factors that directly or indirectly stimulate lymphatic vessel growth (lymphangiogenesis) and lymphatic metastasis. These findings indicate that tumour lymphangiogenesis, similar to haemangiogenesis, is a complex process that is regulated by multiple growth factors. Understanding the underlying mechanisms by which tumours induce lymphangiogenesis might provide important information for the therapeutic intervention of metastatic spread.

PMID:
16079909
DOI:
10.1038/nrc1693
[PubMed - indexed for MEDLINE]
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