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J Clin Invest. 2005 Aug;115(8):2047-58.

ATP-sensitive potassium channelopathies: focus on insulin secretion.

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1
University Laboratory of Physiology, Oxford University, Oxford, United Kingdom. frances.ashcroft@physiol.ox.ac.uk

Abstract

ATP-sensitive potassium (K(ATP)) channels, so named because they are inhibited by intracellular (ATP), play key physiological roles in many tissues. In pancreatic beta cells, these channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes. This review focuses on insulin secretory disorders, such as congenital hyperinsulinemia and neonatal diabetes, that result from mutations in K(ATP) channel genes. It also considers the extent to which defective regulation of K(ATP) channel activity contributes to the etiology of type 2 diabetes.

PMID:
16075046
PMCID:
PMC1180549
DOI:
10.1172/JCI25495
[Indexed for MEDLINE]
Free PMC Article
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