Format

Send to

Choose Destination
J Clin Invest. 2005 Aug;115(8):2018-24.

Long QT syndrome: from channels to cardiac arrhythmias.

Author information

1
Heart Research Follow-up Program, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA. heartajm@heart.rochester.edu

Abstract

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.

PMID:
16075042
PMCID:
PMC1180552
DOI:
10.1172/JCI25537
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Society for Clinical Investigation Icon for PubMed Central
Loading ...
Support Center