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Nat Rev Mol Cell Biol. 2005 Jul;6(7):519-29.

AAA+ proteins: have engine, will work.

Author information

1
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. phanson@cellbiology.wustl.edu

Abstract

The AAA+ (ATPases associated with various cellular activities) family is a large and functionally diverse group of enzymes that are able to induce conformational changes in a wide range of substrate proteins. The family's defining feature is a structurally conserved ATPase domain that assembles into oligomeric rings and undergoes conformational changes during cycles of nucleotide binding and hydrolysis. Here, we review the structural organization of AAA+ proteins, the conformational changes they undergo, the range of different reactions they catalyse, and the diseases associated with their dysfunction.

PMID:
16072036
DOI:
10.1038/nrm1684
[Indexed for MEDLINE]

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