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Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21.

Ubiquitin-binding domains.

Author information

1
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208-3500, USA. l-hicke@northwestern.edu

Abstract

Ubiquitin-binding domains (UBDs) are a collection of modular protein domains that non-covalently bind to ubiquitin. These recently discovered motifs interpret and transmit information conferred by protein ubiquitylation to control various cellular events. Detailed molecular structures are known for a number of UBDs, but to understand their mechanism of action, we also need to know how binding specificity is determined, how ubiquitin binding is regulated, and the function of UBDs in the context of full-length proteins. Such knowledge will be key to our understanding of how ubiquitin regulates cellular proteins and processes.

PMID:
16064137
DOI:
10.1038/nrm1701
[Indexed for MEDLINE]

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