Format

Send to

Choose Destination
See comment in PubMed Commons below
Cancer Res. 2005 Aug 1;65(15):6485-7.

Myc, cell competition, and compensatory proliferation.

Author information

1
Zoologisches Institut, Universitaet Zurich, Zurich, Switzerland. gallant@zool.unizh.ch

Abstract

The proto-oncogene Myc is already known to affect many cellular processes, but recent experiments in the fruit fly Drosophila melanogaster have revealed yet a new facet of Myc. Neighboring cells were shown to compare their Myc levels and the losers (cells with lower Myc activity) were actively eliminated. This phenomenon is called "cell competition," and it seems to be part of a developmental size and quality control program. Subversion of this mechanism may contribute to the transforming powers of Myc and possibly other oncogenes.

PMID:
16061622
DOI:
10.1158/0008-5472.CAN-05-1101
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center