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Bioorg Med Chem. 2005 Nov 15;13(22):6218-25. Epub 2005 Aug 2.

Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners.

Author information

1
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, Andhra Pradesh, India. ahmedkamal@iict.res.in

Abstract

A series of C-4-anilino- and C-4-imido-substituted new podophyllotoxin congeners have been designed, synthesized, and evaluated for their cytotoxicity and DNA topoisomerase-II (topo-II) inhibition potential. Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity.

PMID:
16061385
DOI:
10.1016/j.bmc.2005.06.032
[Indexed for MEDLINE]

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