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Physiol Behav. 2005 Sep 15;86(1-2):18-20.

Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction.

Author information

1
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA. dcsrobts@wfubmc.edu

Abstract

A variety of studies indicate that GABA(B) receptor agonists may be useful in the treatment of addictive disorders. This brief review summarizes self-administration studies in rats which show that baclofen and other GABA(B) agonists may have specific effects on the reinforcing effects of cocaine. Preliminary clinical data with baclofen have also been encouraging. The obstacles and issues related to the use of GABA drugs in addiction therapy are briefly addressed.

PMID:
16061264
DOI:
10.1016/j.physbeh.2005.06.017
[Indexed for MEDLINE]
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