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Arq Neuropsiquiatr. 2005 Jun;63(2B):410-5. Epub 2005 Jul 25.

[Neuromodulatory effects of caffeine and bromazepam on visual event-related potential (P300): a comparative study].

Author information

1
Laboratório de Mapeamento Cerebral e Integração Sensório-Motora, Instituto de Psiquiatria, IPUB, Brazil. marianamoliveira@yahoo.com

Abstract

The P300 component of the event-related potential (ERP) is a general measurement of "cognitive efficiency". It is an index of the ability of an individual's central nervous system (CNS) to process incoming information.

OBJECTIVE:

To compare the neuromodulatory effects of caffeine and bromazepam on the visual ERP (P300), in relation to a P300 normative database.

METHOD:

15 right-handed individuals (7 male and 8 female), between 20 and 30 years of age, healthy, free of any cognitive impairment and not making use of psychoactive substances were studied. Participants were submitted to a visual discrimination task, which employed the "oddball" paradigm, after the administration of caffeine and bromazepam, in a randomized, double-blind design.

RESULTS:

Statistically significant differences were observed when the caffeine and bromazepam conditions were compared to the normative database.

CONCLUSION:

The present results suggest that caffeine and bromazepam have distinct modulatory effects on CNS functioning.

PMID:
16059590
DOI:
/S0004-282X2005000300009
[Indexed for MEDLINE]
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