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Epilepsy Curr. 2004 Sep-Oct;4(5):193-5.

Sleep deprivation and epilepsy.

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Department of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee 37212, USA.


This review summarizes the data for and against sleep deprivation as a facilitator of epileptic seizures and interictal epileptiform discharges. Much of these data are derived from clinical studies; however, basic science investigations are greatly needed to determine the influence of sleep deprivation on seizure susceptibility and neuronal function. Study of the effects of sleep deprivation on epilepsy may create a window of opportunity that could help decipher how seizures are triggered and facilitated, potentially providing an avenue for future interventions.

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