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Nat Cell Biol. 2005 Aug;7(8):758-65.

Ubiquitin signalling in the NF-kappaB pathway.

Author information

1
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA. zhijian.chen@utsouthwestern.edu

Abstract

The transcription factor NF-kappaB (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-kappaB pathway: degradation of IkappaB (inhibitor of NF-kappaB), processing of NF-kappaB precursors, and activation of the IkappaB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.

PMID:
16056267
PMCID:
PMC1551980
DOI:
10.1038/ncb0805-758
[Indexed for MEDLINE]
Free PMC Article

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