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Biophys J. 2005 Oct;89(4):2473-80. Epub 2005 Jul 29.

Thermal fluctuations of red blood cell membrane via a constant-area particle-dynamics model.

Author information

1
Department of Bioengineering, Imperial College London, London, United Kingdom. g.marcelli@imperial.ac.uk

Abstract

We describe a model of the mechanical properties of the cell plasma membrane using a finite-temperature particle-dynamics simulation of the whole cell, in which a two-dimensional network of virtual particles embedded in a three-dimensional closed surface represents the membrane. The particles interact via harmonic potential and dihedral angle potential and are subject to a constant area constraint. The evolution of the positions of the particles yields the equilibrium state of the membrane and allows determination of the membrane thermal fluctuations and the elastic moduli. We show that time-averaging of the cell-model configurations allows quantitative comparison with experimental data on membrane fluctuations and elastic moduli of the red blood cell.

PMID:
16055528
PMCID:
PMC1366746
DOI:
10.1529/biophysj.104.056168
[Indexed for MEDLINE]
Free PMC Article

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