Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Immunol. 2005 Oct;17(5):526-31.

Several genes in the extended human MHC contribute to predisposition to autoimmune diseases.

Author information

1
Institute of Immunology, Rikshospitalet University Hospital, University of Oslo, Norway. b.a.lie@medisin.uio.no

Abstract

Autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, psoriasis and systemic lupus erythematosus, affect approximately 4% of the population in industrialized countries, and are characterized by an immune-mediated destruction of autologous cells and/or tissues. More knowledge is needed to prevent and treat this large group of diseases. Unravelling the genetic predisposing factors is important in this respect, and large research efforts have been initiated to reach this goal. The human MHC, also called the human leukocyte antigen (HLA) complex, is known to harbour major genetic determinants for autoimmune diseases. For several autoimmune diseases certain classical HLA class II and/or class I genes are strongly associated with disease. As a result of recent systematic screening studies additional genes and regions in the MHC, including the extended MHC, are now known to contribute to the predisposition.

PMID:
16054351
DOI:
10.1016/j.coi.2005.07.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center