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Trends Pharmacol Sci. 2005 Sep;26(9):462-9.

The histamine H4 receptor as a new therapeutic target for inflammation.

Author information

1
Leiden/Amsterdam Center for Drug Research, Department of Medicinal Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.

Abstract

Following the sequencing of the human genome, data-mining efforts have revealed the existence of a new histamine receptor that is expressed at high levels in mast cells and leukocytes. The histamine H(4) receptor has a distinct pharmacological profile and the first compounds that act selectively on the H(4) receptor have been developed. Initial experiments in vivo with H(4) receptor antagonists indicate a role for the H(4) receptor in inflammatory conditions.

PMID:
16054239
DOI:
10.1016/j.tips.2005.07.002
[Indexed for MEDLINE]
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