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J Neuroimmunol. 2005 Oct;167(1-2):81-9.

Meningoencephalitic African trypanosomiasis: Brain IL-10 and IL-6 are associated with protection from neuro-inflammatory pathology.

Author information

1
School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen AB24 2TZ, UK. j.sternberg@abdn.ac.uk

Abstract

The relationship of neuropathology to CNS inflammatory and counter-inflammatory cytokine production in African trypanosome-infected mice was studied using an infection model with a defined disease progression. The initial phase of CNS infection by trypanosomes, where only mild neuropathology is evident, was characterised by high levels of IL-10 and IL-6. In the later phase of CNS infection and in a post-drug treatment model, moderate to severe neuropathology was associated with high levels of IFN-gamma and TNF-alpha. The relationship of these cytokines to neuropathological grade suggests that IL-10 and IL-6 protect the CNS from inflammatory pathology when parasites first enter the brain and the data reconcile previously contradictory clinical measurements of CSF cytokines in meningoencephalitic patients with post-mortem histopathology observations.

PMID:
16054238
DOI:
10.1016/j.jneuroim.2005.06.017
[Indexed for MEDLINE]

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