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Cell Metab. 2005 Feb;1(2):85-6.

Getting fat: two new players in molecular adipogenesis.

Author information

1
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, Maryland 20892, USA.

Abstract

A transcription factor cascade drives adipogenesis. Two new members of this cascade have been uncovered--Kruppel-like factor 5 (KLF5), which is induced by C/EBPbeta and delta and acts in concert with C/EBPalpha, beta, and delta to activate PPARgamma2 expression, and Krox20, which is upstream of C/EBPbeta expression and one of the earliest factors induced during adipogenesis.

PMID:
16054047
DOI:
10.1016/j.cmet.2005.01.004
[Indexed for MEDLINE]
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