The natural history of isolated left ventricular diastolic dysfunction

Am J Med. 1992 Jun;92(6):627-30. doi: 10.1016/0002-9343(92)90781-6.

Abstract

Study objective: To assess the natural history of isolated left ventricular diastolic dysfunction.

Patients and methods: Follow-up (average duration, 68 months) was obtained in 51 patients with isolated left ventricular diastolic dysfunction at cardiac catheterization, characterized by (1) an elevated left ventricular end-diastolic pressure; (2) normal left ventricular end-diastolic and end-systolic volumes; (3) normal left ventricular ejection fraction; (4) no coronary artery disease; and (5) no valvular disease.

Results: During follow-up, seven patients died, but only one died of cardiac causes. Of the 44 living subjects, 20 (45%) noted new-onset symptoms of congestive heart failure, with 11 (25%) of these requiring hospitalization, and 12 (27%) required hospitalization for recurrent chest pain.

Conclusions: Isolated left ventricular diastolic dysfunction is associated with a low cardiac mortality; at the same time, however, it is associated with substantial morbidity.

MeSH terms

  • Adult
  • Aged
  • Blood Pressure
  • Cardiac Catheterization
  • Chest Pain / epidemiology
  • Chest Pain / etiology
  • Diastole*
  • Female
  • Follow-Up Studies
  • Heart Diseases / complications*
  • Heart Diseases / diagnosis
  • Heart Diseases / mortality
  • Heart Failure / epidemiology
  • Heart Failure / etiology
  • Hospitals, Urban
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Pulmonary Wedge Pressure
  • Stroke Volume*
  • Survival Analysis
  • Texas / epidemiology
  • Ventricular Function, Left*