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Curr Biol. 2005 Jul 26;15(14):R563-74.

Signaling interplay in Ras superfamily function.

Author information

1
University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, NC 27599, USA. natalia_mitin@med.unc.edu

Abstract

Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that have significant sequence and biochemical similarities. Recent observations have established a complex signaling interplay between Ras and other members of the family. A key biochemical mechanism facilitating this crosstalk involves guanine nucleotide exchange factors (GEFs), which serve as regulators and effectors, as well as signaling integrators, of Ras signaling.

PMID:
16051167
DOI:
10.1016/j.cub.2005.07.010
[Indexed for MEDLINE]
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