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Curr Biol. 2005 Jul 26;15(14):R563-74.

Signaling interplay in Ras superfamily function.

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University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, NC 27599, USA.


Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that have significant sequence and biochemical similarities. Recent observations have established a complex signaling interplay between Ras and other members of the family. A key biochemical mechanism facilitating this crosstalk involves guanine nucleotide exchange factors (GEFs), which serve as regulators and effectors, as well as signaling integrators, of Ras signaling.

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