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Cell. 2005 Jul 29;122(2):147-9.

And the noise played on: stochastic gene expression and HIV-1 infection.

Author information

1
Center for BioDynamics and Department of Biomedical Engineering, Boston University, MA 02215, USA.

Abstract

Stochastic gene expression has been implicated in a variety of cellular processes, including cell differentiation and disease. In this issue of Cell, take an integrated computational-experimental approach to study the Tat transactivation feedback loop of HIV-1. They show that fluctuations in a key regulator, Tat, in an isogenic population of infected cells result in two distinct expression states corresponding to latent and productive HIV-1 infection. These findings demonstrate the importance of stochastic gene expression in molecular "decision-making."

PMID:
16051138
DOI:
10.1016/j.cell.2005.07.006
[Indexed for MEDLINE]
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