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Nature. 2005 Jul 28;436(7050):518-24.

Genes that mediate breast cancer metastasis to lung.

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1
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Abstract

By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.

PMID:
16049480
PMCID:
PMC1283098
DOI:
10.1038/nature03799
[Indexed for MEDLINE]
Free PMC Article
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