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Reproduction. 2005 Aug;130(2):131-45.

Leukaemia inhibitory factor in implantation and uterine biology.

Author information

1
Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. sue.kimber@manchester.ac.uk

Abstract

Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence on reproductive tract cells such as leukocytes and glandular epithelium, during the pre-implantation phase of pregnancy.

PMID:
16049151
DOI:
10.1530/rep.1.00304
[Indexed for MEDLINE]

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