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Antimicrob Agents Chemother. 2005 Aug;49(8):3529-32.

Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice.

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  • 1Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd., Cleveland, OH 44106, USA.

Abstract

In mice, subcutaneous administration of antibiotics that disrupt the anaerobic microflora (i.e., clindamycin, piperacillin-tazobactam, and ceftriaxone) facilitated in vitro growth of and toxin production by Clostridium difficile in cecal contents, whereas antibiotics that cause minimal disruption of the anaerobic microflora (i.e., levofloxacin, cefepime, and aztreonam) did not.

PMID:
16048976
PMCID:
PMC1196291
DOI:
10.1128/AAC.49.8.3529-3532.2005
[PubMed - indexed for MEDLINE]
Free PMC Article
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