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Antimicrob Agents Chemother. 2005 Aug;49(8):3523-5.

Origin of plasmid-mediated quinolone resistance determinant QnrA.

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  • 1Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78, rue du General Leclerc, 94275 Le Kremlin-Bicêtre, France.

Abstract

Plasmid-mediated resistance to quinolones is increasingly reported in studies of Enterobacteriaceae. Using a PCR-based strategy, a series of gram-negative species were screened for qnrA-like genes. Shewanella algae, an environmental species from marine and fresh water, was identified as its reservoir. This is a one of the very few examples of progenitor identification of an acquired antibiotic resistance gene.

PMID:
16048974
PMCID:
PMC1196254
DOI:
10.1128/AAC.49.8.3523-3525.2005
[PubMed - indexed for MEDLINE]
Free PMC Article
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