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Immunol Rev. 2005 Aug;206:219-31.

Innate and adaptive immunity: the yin and yang of celiac disease.

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Department of Pathology, Medicine and Pediatrics, University of Chicago, Chicago, IL 60637, USA.


Celiac disease is a multigenetic complex inflammatory disorder with an autoimmune component, induced by gluten, a protein found in wheat. It is a unique human disease model to dissect the innate and adaptive immune mechanisms underlying T-cell-mediated tissue destruction and the development of T-cell lymphoma in conditions of chronic T-cell activation.

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